4 research outputs found
Repolarization parameters in patients with acute ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention with respect to predischarge ST-T pattern: A preliminary study
Background: Negative T wave and lack of ST segment elevation in predischarge ECG in
ST-segment elevation myocardial infraction (STEMI) patients are given as markers of good
prognosis. Repolarization duration, especially its late part (TpeakTend - TpTe), likewise
ST-T patterns, is related to local post-myocardial infarction myocardial attributes. We analyzed
the differences in QT parameters in STEMI patients with negative or not-negative T wave
pattern in predischarge ECG.
Methods: The data from 83 STEMI patients (LVEF > 45%, first MI, one-vessel disease)
who underwent successful percutaneous coronary intervention of infarct-related coronary artery
(TIMI 3 flow) were collected. According to ST-T patterns in predischarge ECG, the cohort
was divided into two groups: 38 patients with persistent ST elevation and/or non-negative
T wave pattern (STT+), and 45 patients with negative T wave, without ST elevation (STT-).
QT, QTpeak, and TpTe intervals were obtained from 5 consecutive beats of sinus rhythm
60–70 bpm between 6 a.m. and 8 a.m. from Holter recording, corrected to the heart rate (HR)
with Bazett’s formula.
Results: The study groups did not differ in gender, age, or treatment. No true antiarrhythmics
were given. Both QTc and TpTec were longer in STT+ patients: 459 ± 26 ms vs. 440 ± 25 ms,
p = 0.01 and 108 ± 10 ms vs. 96 ± 11 ms, p = 0.000015, respectively. Prolongation of late
repolarization was found both in anterior and inferior infarction.
Conclusions: STEMI patients who underwent successful percutaneous coronary intervention
of infarct-related coronary arteries and demonstrated persistent ST elevation, without
negative T wave at hospital discharge, had a longer repolarization duration, especially the late
phase of it. Further studies are necessary to assess the prognostic value of this finding